-
- Michael P Dwyer, Younong Yu, Jianping Chao, Cynthia Aki, Jianhua Chao, Purakkattle Biju, Viyyoor Girijavallabhan, Diane Rindgen, Richard Bond, Rosemary Mayer-Ezel, James Jakway, R William Hipkin, James Fossetta, Waldemar Gonsiorek, Hong Bian, Xuedong Fan, Carol Terminelli, Jay Fine, Daniel Lundell, J Robert Merritt, Laura L Rokosz, Bernd Kaiser, Ge Li, Wei Wang, Tara Stauffer, Lynne Ozgur, John Baldwin, and Arthur G Taveras.
- Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. michael.dwyer@spcorp.com
- J. Med. Chem. 2006 Dec 28; 49 (26): 7603-6.
AbstractStructure-activity studies on lead cyclobutenedione 3 led to the discovery of 4 (SCH 527123), a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist with excellent cell-based activity. Compound 4 displayed good oral bioavailability in rat and may be a potential therapeutic agent for the treatment of various inflammatory diseases.
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