• Congmin Wang, Mingguang Zhang, Chifei Sun, Yuqun Cai, Yan You, Liping Huang, and Fang Liu.
• Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, 200032 Shanghai, People's Republic of China.
• Neurosci. Lett. 2011 Jan 13; 488 (1): 70-5.

AbstractIt is known that the number of newly generated neurons is increased in the young and adult rodent subventricular zone (SVZ) and dentate gyrus (DG) after transient brain ischemia. However, it remains unclear whether increase in neurogenesis in the adult DG induced by ischemic stroke is transient or sustained. We here reported that from 2 weeks to 6 months after transient middle cerebral artery occlusion (MCAO), there were more doublecortin positive (DCX+) cells in the ipsilateral compared to the sham-control and contralateral DG of the adult rat. After the S-phase marker 5-bromo-2'-deoxyuridine (BrdU) was injected 2 days after MCAO to label newly generated cells, a large number of BrdU-labeled neuroblasts differentiated into mature granular neurons. These BrdU-labeled neurons survived for at least 6 months. When BrdU was injected 6 weeks after injury, there were still more newly generated neuroblasts differentiated into mature neurons in the ipsilateral DG. Altogether, our data indicate that transient brain ischemia initiates a prolonged increase in neurogenesis and promotes the normal development of the newly generated neurons in the adult DG.Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

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