• Internal medicine · Mar 2002

    Case Reports

    Treatment of bronchorrhea by corticosteroids in a case of bronchioloalveolar carcinoma producing CA19-9.

    • Takeshi Nakajima, Takeshi Terashima, Jiro Nishida, Masami Onoda, and Osamu Koide.
    • Department of Internal Medicine, Ichikawa General Hospital, Tokyo Dental College, Ichikawa.
    • Intern. Med. 2002 Mar 1; 41 (3): 225-8.

    AbstractA case of gastrointestinal cancer-associated antigen (CA19-9)-positive bronchioloalveolar carcinoma accompanied by bronchorrhea and respiratory failure successfully treated with corticosteroids is reported. The patient was treated with pulse methylprednisolone at a dose of 1,000 mg/day for three days, followed by oral prednisolone (60 mg/day). Within 2 days, the sputum volume decreased from >100 ml/day to 20 ml/day and it was finally controlled to 0-10 ml/day. The reduction in the sputum volume was associated with alleviation of dyspnea and hypoxemia. The levels of CA19-9 in the serum and the sputum were extremely high and an immunocytochemical study showed that the tumor cells were stained by CA19-9 antibody. This case demonstrates the therapeutic value of corticosteroids in the treatment of bronchorrhea in subjects with bronchioloalveolar carcinoma.

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