• Rajendra Kumar, Jeanne M Meis, Behrang Amini, Kevin W McEnery, John E Madewell, Laurence D Rhines, and Robert S Benjamin.
• *Department of Diagnostic Radiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX †Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX ‡Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX §Department of Sarcoma Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
• Spine. 2017 May 15; 42 (10): E629-E632.

Study DesignCase report and literature review.ObjectiveTo describe treatment of a unique case of acute airway obstruction by a large C7 giant cell tumor (GCT) with preoperative denosumab followed by surgical resection, and review the literature on this rare entity.Summary Of Background DataStandard treatment for GCTs includes surgical resection or curettage and packing. Large lesions in the spine may require preoperative therapy with denosumab, a human monoclonal antibody to RANKL, to facilitate surgery. It is highly unusual for GCT arising in cervical spine to present with acute asphyxia (requiring tracheostomy).MethodsWe report a patient with large C7 GCT that caused tracheal compression with almost complete airway obstruction requiring emergency intubation.ResultsThe tumor responded to subcutaneously administered denosumab with marked decrease in size and relief of symptoms. Increased tumor mineralization in response to therapy facilitated subsequent successful surgical tumor resection. The patient remains symptom-free 2 years after surgery without tumor recurrence.ConclusionDenosumab can shrink the size of large GCTs, providing symptom relief before surgery and facilitate tumor resection.Level Of Evidence5.

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