• Qian Zhou, Yucheng Wang, Lei Yi, Zhigang Tan, and Yugang Jiang.
• Department of Neurosurgery, Second Xiangya Hospital of Central South University, Changsha, China; School of Materials Science and Engineering, Central South University, Changsha, China.
• World Neurosurg. 2017 Feb 1; 98: 251-257.

BackgroundThe primary auditory cortex, which was previously considered to be unisensory, has been shown to be multisensory. However, the temporal details of processing nonauditory stimuli in the human auditory cortex remain unclear, owing to the low temporal and spatial resolution of the adopted imaging techniques.MethodsUsing intraoperative optical imaging of intrinsic signals recording techniques, detailed cortical activations within the auditory cortex in response to auditory and somatosensory stimulation were recorded from 3 intraoperative anesthetized patients with brain tumors located in the superior temporal gyrus.ResultsAt both green-light (545 nm ± 13) and red-light (610 nm ± 10) illumination, the primary and secondary auditory cortices responded significantly to the somatosensory stimulation. As induced by the somatosensory stimulus, the average overlapping rate of the activated region was 74.51% ± 0.15, and the peak responding time occurred at poststimulus 7-8 seconds. There was no significant difference in the peak responding time between auditory and somatosensory stimuli (P < 0.01, paired t test).ConclusionsThese findings provide novel evidence for multisensory interplay within human auditory cortex at an early stage of cortical processing, which extends the understanding of multisensory mechanisms of human brain functions.Copyright © 2016 Elsevier Inc. All rights reserved.

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