• Am. J. Transplant. · Dec 2007

    Case Reports

    Cellulitis revealing a cryptococcosis-related immune reconstitution inflammatory syndrome in a renal allograft recipient.

    • F Lanternier, M-O Chandesris, S Poirée, M-E Bougnoux, F Mechai, M-F Mamzer-Bruneel, J-P Viard, L Galmiche-Rolland, M Lecuit, and O Lortholary.
    • Service des Maladies Infectieuses et Tropicales Hôpital Necker-Enfants Malades, Université Paris V Centre d'Infectiologie Necker-Pasteur, Paris, Cedex 15, France.
    • Am. J. Transplant. 2007 Dec 1; 7 (12): 2826-8.

    AbstractImmune reconstitution inflammatory syndrome (IRIS) has rarely been described in the course of disseminated cryptococcosis in solid organ transplant recipients. We report here the case of a renal transplant recipient who developed severe cellulitis in the context of Cryptococcus neoformans-associated IRIS while undergoing reduction of his immunosuppressive therapy. IRIS appeared concomitantly with a dramatic increase of blood CD4+ T cells (94-460/mm(3)) and required the administration of a short-term steroid therapy to resolve.

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