• Lin-na Wang, He-yi Zheng, Jun Li, Xiao-feng Wang, and Xiu-rong Liu.
• Department of Dermatology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing 100730, China.
• Zhonghua Yi Xue Za Zhi. 2007 Jun 26; 87 (24): 1721-2.

ObjectiveTo compare the sensitivity and specificity between ELISA based on the recombinant Treponema pallidum (Tp) antigen and rapid plasma reagin (RPR) test diagnosis of syphilis.MethodsPeripheral blood samples were collected from 249 patients, 177 males and 72 females, aged 34. Abbott Determine Syphilis TP test (ELISA based on the recombinant Tp antigen), RPR test, and Treponema pallidum haemagglutination assay (TPHA) were conducted with TPHA used as the gold standard.ResultsThe serum sensitivity and specificity of Abbott Determine Syphilis TP test were 100% and 98.4% respectively. The serum sensitivity and specificity of RPR test were 65.1% and 98.4% respectively.ConclusionThe sensitivity of the rapid ELISA based on recombinant Tp antigen is significantly higher than that of RPR test.

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