• Am J Emerg Med · Feb 2017

    Observational Study

    Sex-based differences in prevalence and clinical presentation among pericarditis and myopericarditis patients.

    • Michal Laufer-Perl, Ofer Havakuk, Yacov Shacham, Arie Steinvil, Sivan Letourneau-Shesaf, Ehud Chorin, Gad Keren, and Yaron Arbel.
    • Department of Cardiology, Tel-Aviv Sourasky Medical Center, Tel Aviv, affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: michalpela@gmail.com.
    • Am J Emerg Med. 2017 Feb 1; 35 (2): 201-205.

    BackgroundSex differences in heart diseases, including acute coronary syndrome, congestive heart failure, and atrial fibrillation, have been studied extensively. However, data are lacking regarding sex differences in pericarditis and myopericarditis patients.ObjectivesThe purpose of the study was to evaluate whether there are sex differences in pericarditis and myopericarditis patients as well.MethodsWe performed a retrospective, single-center observational study that included 200 consecutive patients hospitalized with idiopathic pericarditis or myopericarditis from January 2012 to April 2014. Patients were evaluated for sex differences in prevalence, clinical presentation, laboratory variables, and outcome. We excluded patients with a known cause for pericarditis.ResultsAmong 200 consecutive patients, 55 (27%) were female. Compared with men, women were significantly older (60±19 years vs 46±19 years, P<.001) and had a higher rate of chronic medical conditions. Myopericarditis was significantly more common among men (51% vs 25%, P=.001). Accordingly, men had significantly higher levels of peak troponin (6.8±17 ng/mL vs 0.9±2.6 ng/mL, P<.001), whereas women presented more frequently with pericardial effusion (68% vs 45%, P=.006). Interestingly, women had a significantly lower rate of hospitalization in the cardiology department (42% vs 63%, P=.015). Overall, there were no significant differences in ejection fraction, type of treatment, complications, or in-hospital mortality.ConclusionsMost patients admitted with acute idiopathic pericarditis are male. In addition, men have a higher prevalence of myocardial involvement. Significant sex differences exist in laboratory variables and in hospital management; however, the outcome is similar and favorable in both sexes.Copyright © 2016 Elsevier Inc. All rights reserved.

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