• Martin Kaipel, Sebastian Schützenberger, Arthur Schultz, James Ferguson, Paul Slezak, Tatjana J Morton, Martijn Van Griensven, and Heinz Redl.
• Orthopaedic Department, Barmherzige Brüder Hospital, Esterhazystrasse 26, A-7000 Eisenstadt, Austria. martin.kaipel@bbeisen.at
• J. Orthop. Res. 2012 Oct 1; 30 (10): 1563-9.

AbstractTreatment of delayed bone healing and non-unions after fractures, osteotomies or arthrodesis still is a relevant clinical challenge. Artificially applied growth factors can increase bone healing and progressively gain importance in clinical routine. The aim of this study was to determine the effects of rhPDGF-BB, rhVEGF-165, and rhBMP-2 in fibrin matrix on bone healing in a delayed-union rat model. Thirty-seven rats underwent a first operation where a standardized femoral critical size defect was created. A silicone spacer was implanted to impair vascularization within the defect. At 4 weeks the spacer was removed in a second operation and rhPDGF-BB, rhVEGF-165, or rhBMP-2 were applied in a fibrin clot. Animals in a fourth group received a fibrin clot without growth factors. At 8 weeks fibrin bound rhBMP-2 treated animals showed a significantly increased union rate and bone volume within the defect compared to the other groups. Single application of fibrin bound rhPDGF-BB and rhVEGF-165 failed to increase bone healing in our atrophic non-union model.Copyright © 2012 Orthopaedic Research Society.

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