• Athanasios Chalkias, Fotios Pavlopoulos, Anastasios Koutsovasilis, Ernesto d'Aloja, and Theodoros Xanthos.
• National and Kapodistrian University of Athens, Medical School, M.Sc. "Cardiopulmonary Resuscitation", Athens, Greece; Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece; Tzaneio General Hospital, Department of Anesthesiology, Piraeus, Greece. Electronic address: thanoschalkias@yahoo.gr.
• Resuscitation. 2017 Jan 1; 110: 101-106.

AimTo assess the usefulness of airway pressure as predictor of return of spontaneous circulation (ROSC), as well as to investigate the optimized ventilation compression strategy during cardiopulmonary resuscitation (CPR).MethodsIn this prospective observational study, 300 out-of-hospital cardiac arrest victims were intubated and resuscitated with the use of a ventilator. Mean airway pressure (mPaw) was measured at pre-defined phases of CPR.ResultsA significant difference in mPaw was observed between survivors and non-survivors after the onset of the third minute of CPR. An mPaw value of 42.5mbar during CPR had specificity and sensitivity of 0.788 and 0.804, respectively, for ROSC (AUC=0.668, p=0.047). During CPR, we found statistically significant differences in mPaw at phases zero (F=4.526, p=0.002), two (F=4.506, p=0.002), four (F=8.187, p<0.0001), five (F=2.871, p=0.024), and six (F=5.364, p<0.0001).ConclusionMean airway pressure was higher in survivors. A value of 42.5mbar was associated with ROSC.Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

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