• WuSi YuSYDepartment of Orthopedics, Daping Hospital, Third Military Medical University, Chongqing, 400042, PR China., HanGeng FenGFDepartment of Orthopedics, Daping Hospital, Third Military Medical University, Chongqing, 400042, PR China., Jian Yi Kang, Liang Chao Zhang, WangAi MinAMDepartment of Orthopedics, Daping Hospital, Third Military Medical University, Chongqing, 400042, PR China. trauma3@163.com., and Jian Min Wang.
• Department of Orthopedics, Daping Hospital, Third Military Medical University, Chongqing, 400042, PR China.
• Ulus Travma Acil Cer. 2016 Sep 1; 22 (5): 405-411.

BackgroundVascular leakage has been proven to play a critical role in the incidence and development of explosive pulmonary barotrauma. Quantitatively investigated in the present study was the severity of vascular leakage in a gradient blast injury series, as well as ultrastructural evidence relating to pulmonary vascular leakage.MethodsOne hundred adult male New Zealand white rabbits were randomly divided into 5 groups according to distance from the detonator (10 cm, 15 cm, 20 cm, 30 cm, and sham control). Value of pulmonary vascular leakage was monitored by a radioactive 125I-albumin labeling method. Pathological changes caused by the blast wave were examined under light and electron microscopes.ResultsTranscapillary escape rate of 125I-albumin and residual radioactivity in both lungs increased significantly at the distances of 10 cm, 15 cm, and 20 cm, suggesting increased severity of vascular leakage in these groups. Ultrastructural observation showed swelling of pulmonary capillary endothelial cells and widened gap between endothelial cells in the 10-cm and 15-cm groups.ConclusionPrimary blast wave can result in pulmonary capillary blood leakage. Blast wave can cause swelling of pulmonary capillary endothelial cells and widened gap between endothelial cells, which may be responsible for pulmonary vascular leakage.

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