• Eur. Respir. J. · Feb 2008

    Review

    Outcomes for COPD pharmacological trials: from lung function to biomarkers.

    • M Cazzola, W MacNee, F J Martinez, K F Rabe, L G Franciosi, P J Barnes, V Brusasco, P S Burge, P M A Calverley, B R Celli, P W Jones, D A Mahler, B Make, M Miravitlles, C P Page, P Palange, D Parr, M Pistolesi, S I Rennard, M P Rutten-van Mölken, R Stockley, S D Sullivan, J A Wedzicha, E F Wouters, American Thoracic Society, and European Respiratory Society Task Force on outcomes of COPD.
    • Unit of Respiratory Diseases, Dept of Internal Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy. mario.cazzola@uniroma2.it
    • Eur. Respir. J. 2008 Feb 1; 31 (2): 416-69.

    AbstractThe American Thoracic Society/European Respiratory Society jointly created a Task Force on "Outcomes for COPD pharmacological trials: from lung function to biomarkers" to inform the chronic obstructive pulmonary disease research community about the possible use and limitations of current outcomes and markers when evaluating the impact of a pharmacological therapy. Based on their review of the published literature, the following document has been prepared with individual sections that address specific outcomes and markers, and a final section that summarises their recommendations.

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