• Critical care clinics · Jan 2017

    Review

    Coagulopathy of Trauma.

    • Mitchell J Cohen and S Ariane Christie.
    • Department of Surgery, San Francisco General Hospital, University of California, San Francisco, School of Medicine, 1001 Potrero Avenue, San Francisco, CA 94110, USA. Electronic address: Mitchell.Cohen@ucsf.edu.
    • Crit Care Clin. 2017 Jan 1; 33 (1): 101-118.

    AbstractCoagulopathy is common after injury and develops independently from iatrogenic, hypothermic, and dilutional causes. Despite considerable research on the topic over the past decade, trauma-induced coagulopathy (TIC) continues to portend poor outcomes, including decreased survival. We review the current evidence regarding the diagnosis and mechanisms underlying trauma induced coagulopathy and summarize the debates regarding optimal management strategy including product resuscitation, potential pharmacologic adjuncts, and targeted approaches to hemostasis. Throughout, we will identify areas of continued investigation and controversy in the understanding and management of TIC.Copyright © 2016 Elsevier Inc. All rights reserved.

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