• Critical care clinics · Jan 2017

    Review

    Tranexamic Acid Update in Trauma.

    • Ricardo J Ramirez, Philip C Spinella, and Grant V Bochicchio.
    • Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.
    • Crit Care Clin. 2017 Jan 1; 33 (1): 85-99.

    AbstractFollowing results from the CRASH-2 trial, tranexamic acid (TXA) gained considerable interest for the treatment of hemorrhage in trauma patients. Although TXA is effective at reducing mortality in patients presenting within 3 hours of injury, optimal dosing, timing of administration, mechanism, and pharmacokinetics require further elucidation. The concept of fibrinolysis shutdown in hemorrhagic trauma patients has prompted discussion of real-time viscoelastic testing and its potential role for appropriate patient selection. The results of ongoing clinical trials will help establish high-quality evidence for optimal incorporation of TXA in mature trauma networks in the United States and abroad.Copyright © 2016. Published by Elsevier Inc.

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