• Youngjin Kim, Myung-Hoon Han, Choong-Hyun Kim, Jae-Min Kim, Jin-Hwan Cheong, and Je-Il Ryu.
• Department of Neurosurgery, Hanyang University Guri Hospital, Guri, Gyonggi-do, Korea.
• World Neurosurg. 2017 Feb 1; 98: 503-511.

ObjectiveSpontaneous intracerebral hemorrhage (ICH) can be a devastating event. An increased glucose level in patients with ICH is known to be related to poor outcomes, including acute leukocytosis, which is a well-established response to ICH. The purpose of this study was to evaluate the association between admission laboratory factors and 3-month mortality in patients with spontaneous supratentorial ICH.MethodsWe performed a Kaplan-Meier analysis to evaluate the risk factors for 3-month mortality in patients with ICH. We used univariate and multivariate Cox regression analyses to calculate hazard ratios with 95% confidence intervals for short-term mortality based on clinical and laboratory factors. The area under the receiver operating characteristic curve was used to determine the laboratory risk factors that predicted mortality.ResultsIn total, 538 patients from our hospital admitted with primary spontaneous supratentorial ICH over an 8-year period were enrolled in this study. Higher leukocyte counts (hazard ratio, 1.019; 95% confidence interval, 1.012-1.027; P < 0.001) and glucose levels on admission were associated with higher 3-month mortality. The receiver operating characteristic curve analysis showed that the areas under the curve of ICH volume, glucose, and leukocyte counts were 0.696 (cutoff value, 41.63), 0.687 (cutoff value, 134), and 0.642 (cutoff value, 9.4), respectively.ConclusionsHigher admission white blood cell counts and glucose levels were associated with higher 3-month mortality in patients with spontaneous ICH. These data show that an altered glucose metabolism and inflammatory state after ICH may be related to early deterioration after an ICH.Copyright © 2016 Elsevier Inc. All rights reserved.

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