• Brian Meier and Catherine Staton.
• Division of Emergency Medicine, Department of Surgery, Duke University Medical Center, DUMC Box 3096, 2301 Erwin Road, Duke North, Suite 2600, Durham, NC 27710, USA; Duke Global Health Institute, Trent Hall, 310 Trent Drive, Durham, NC 27710, USA. Electronic address: brian.meier@duke.edu.
• Emerg. Med. Clin. North Am. 2017 Feb 1; 35 (1): 159-173.

AbstractOur evolving understanding of the physiologic processes that lead to sepsis has led to updated consensus guidelines outlining priorities in the recognition and treatment of septic patients. However, an enormous question remains when considering how to best implement these guidelines in settings with limited resources, which include rural US emergency departments and low- and middle-income countries. The core principles of sepsis management should be a priority in community emergency departments. Similarly, cost-effective interventions are key priorities in low- and middle-income countries; however, consideration must be given to the unique challenges associated with such settings.Copyright © 2016 Elsevier Inc. All rights reserved.

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