• Kikuko Suga, Yoshiro Kobayashi, and Ryoichi Ochiai.
• Department of Anesthesia, Kawasaki Municipal Hospital, Kanagawa, Japan; Department of Anesthesiology, Toho University, School of Medicine, Tokyo, Japan. Electronic address: kikuko-suga@ktb.biglobe.ne.jp.
• J. Cardiothorac. Vasc. Anesth. 2017 Aug 1; 31 (4): 1197-1202.

ObjectiveThe aim of this study was to reveal the mechanism of improved arterial oxygenation by measuring the changes in oxygenation before and after initiation of left heart bypass (LHB) during one-lung ventilation (OLV) for thoracic aortic surgery.DesignProspective, observational study.SettingSingle-institution, private hospital.ParticipantsThe study comprised 50 patients who underwent aortic surgery via a left thoracotomy approach with LHB circulatory support.InterventionsPatients were ventilated using pure oxygen during OLV, and the ventilator setting was left unchanged during the measurement period.Measurements And Main ResultsThe measurement of partial pressure of arterial oxygen (PaO2) was made at the following 4 time points: 2 minutes after heparin infusion (point 1 [P1]), 2 minutes after inflow cannula insertion through the left pulmonary vein (P2), immediately before LHB initiation (P3), and 10 minutes after LHB initiation (P4). The mean±standard deviation (mmHg) of PaO2 measurements at the P1, P2, P3, and P4 time points were 244±121, 250±123, 419±122, and 430±109, respectively, with significant increases between P1 and P3, P1 and P4, P2 and P3, and P2 and P4 (p<0.0001, respectively). No significant increase in PaO2 was seen between P1 and P2 or between P3 and P4.ConclusionsThe improved arterial oxygenation during OLV in patients who underwent thoracic aortic surgery using LHB can be attributed to the insertion of an inflow cannula via the left pulmonary vein into the left atrium before LHB.Copyright © 2017 Elsevier Inc. All rights reserved.

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