• B Nascimento, J Callum, H Tien, H Peng, S Rizoli, P Karanicolas, A Alam, W Xiong, R Selby, A-M Garzon, C Colavecchia, R Howald, A Nathens, and A Beckett.
• Sunnybrook Health Sciences Centre, Toronto, ON, Canada Barto.Nascimento@sunnybrook.ca.
• Br J Anaesth. 2016 Dec 1; 117 (6): 775-782.

BackgroundDecreased plasma fibrinogen concentration shortly after injury is associated with higher blood transfusion needs and mortality. In North America and the UK, cryoprecipitate transfusion is the standard-of-care for fibrinogen supplementation during acute haemorrhage, which often occurs late during trauma resuscitation. Alternatively, fibrinogen concentrate (FC) can be beneficial in trauma resuscitation. However, the feasibility of its early infusion, efficacy and safety remain undetermined. The objective of this trial was to evaluate the feasibility, effect on clinical and laboratory outcomes and complications of early infusion of FC in trauma.MethodsFifty hypotensive (systolic arterial pressure ≤100 mm Hg) adult patients requiring blood transfusion were randomly assigned to either 6 g of FC or placebo, between Oct 2014 and Nov 2015 at a tertiary trauma centre. The primary outcome, feasibility, was assessed by the proportion of patients receiving the intervention (FC or placebo) within one h of hospital arrival. Plasma fibrinogen concentration was measured, and 28-day mortality and incidence of thromboembolic events were assessed.ResultsOverall, 96% (43/45) [95% CI 86-99%] of patients received the intervention within one h; 95% and 96% in the FC and placebo groups, respectively (P=1.00). Plasma fibrinogen concentrations remained higher in the FC group up to 12 h after admission with the largest difference at three h (2.9 mg dL -  1 vs. 1.8 mg dL -  1; P<0.01). The 28-day mortality and thromboembolic complications were similar between groups.ConclusionsEarly infusion of FC is feasible and increases plasma fibrinogen concentration during trauma resuscitation. Larger trials are justified.© The Author 2016. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

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