• J. Cardiothorac. Vasc. Anesth. · Aug 2017

    Randomized Controlled Trial

    Effect of Perioperative Pregabalin on Postoperative Quality of Recovery in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting (OPCABG): A Prospective, Randomized, Double-Blind Trial.

    • Deepak Prakash Borde, Savani Sameer Futane, Balaji Asegaonkar, Pramod Apsingekar, Sujeet Khade, Bapu Khodve, Manish Puranik, Antony George, and Shreedhar Joshi.
    • Ozone Anesthesia Group, Aurangabad, Maharashtra, India. Electronic address: deepakborde2482@gmail.com.
    • J. Cardiothorac. Vasc. Anesth. 2017 Aug 1; 31 (4): 1241-1245.

    ObjectivesUse of pregabalin is increasing in cardiac surgical patients. However, studies using comprehensive scoring systems are lacking on the drug's impact on postoperative recovery. The authors tested the hypothesis that perioperative oral pregabalin improves the postoperative quality of recovery as assessed using the Quality of Recovery (QoR-40) questionnaire in patients undergoing off-pump coronary artery bypass grafting (OPCABG).DesignThis was a randomized, double-blind, placebo-controlled study.SettingsTertiary-care hospital.ParticipantsPatients undergoing OPCABG.InterventionsPatients were assigned randomly to the following 2 groups: the pregabalin group (those who received pregabalin, 150 mg capsule orally, 1 hour before surgery and 2 days postoperatively [75 mg twice a day] starting after extubation; n = 37); and the control group (those who received 2 similar-looking multivitamin capsules at similar times; n = 34). The QoR-40 scores were noted preoperatively and 24 hours after extubation.Measurements And Main ResultsBoth groups were comparable in terms of preoperative patient characteristics and baseline QoR-40 scores. Global scores were significantly improved in the pregabalin group compared with the control group in the postoperative period (177±9 v 170±9; p = 0.002). QoR-40 values in the dimensions of emotional state (p = 0.005), physical comfort (p = 0.04), and pain (p = 0.02) were improved in the pregabalin group.ConclusionsPerioperative pregabalin improved postoperative quality of recovery as assessed using the QoR-40 questionnaire in patients undergoing OPCABG. Perioperative pregabalin offered advantages beyond better pain control, such as improved physical comfort and better emotional state; therefore, the drug's use in the perioperative period is recommended.Copyright © 2017 Elsevier Inc. All rights reserved.

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