• Lancet · Jun 2017

    Review

    HER2-positive breast cancer.

    • Sibylle Loibl and Luca Gianni.
    • German Breast Group, c/o GB Forschungs GmbH, Neu-Isenburg, Germany. Electronic address: sibylle.loibl@gbg.de.
    • Lancet. 2017 Jun 17; 389 (10087): 2415-2429.

    AbstractAnti-HER2 treatment for HER2-positive breast cancer has changed the natural biology of this disease. This Series article reviews the main achievements so far in the treatment of both metastatic and early HER2-positive breast cancer. The success of neoadjuvant therapy in HER2-positive early breast cancer is especially acknowledged, as pertuzumab has been approved on the basis of a higher proportion of patients achieving a pathological complete response with pertuzumab and trastuzumab than with trastuzumab alone in a neoadjuvant study. Event-free survival after the confirmatory adjuvant trial completed recruitment was numerically better with pertuzumab plus trastuzumab than with trastuzumab alone. With survival rates of almost 5 years in women with metastatic HER2-positive breast cancer and 75% of patients achieving a pathological complete response, new treatments in the past decade have clearly improved the prognosis of HER2-positive breast cancer. Despite these achievements, however, the persisting high toll of deaths resulting from HER2-positive breast cancer calls for continued, intensive clinical research of newer therapies and combinations.Copyright © 2017 Elsevier Ltd. All rights reserved.

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