• Carlo Di Bonaventura, Marco Carni, Erica Diani, Jinane Fattouch, Elisabetta A Vaudano, Gabriella Egeo, Patrizia Pantano, Bruno Maraviglia, Luigi Bozzao, Mario Manfredi, Massimiliano Prencipe, Teresa A Giallonardo, and Carlo Nobile.
• Department of Neurological Sciences, University of Rome, Rome, Italy. c_dibonaventura@yahoo.it
• Epilepsia. 2009 Nov 1; 50 (11): 2481-6.

PurposeWe characterized a family with autosomal dominant lateral temporal epilepsy (ADLTE) whose proband presented uncommon electroclinical findings such as drug-resistant seizures and recurrent episodes of status epilepticus with dysphasic features.MethodsThe electroclinical characteristics and LGI1 genotype were defined in the family. In the proband, the ictal pattern was documented during video-EEG monitoring and epileptic activity was mapped by EEG/fMRI.ResultsThe affected members who were studied had drug-resistant seizures. In the proband, seizures with predominant dysphasic features often occurred as partial status epilepticus. The video-EEG-documented ictal activity and fMRI activation clearly indicated the elective involvement of the left posterior lateral temporal cortex. Sequencing of LGI1 exons revealed a heterozygous c.367G>A mutation in exon 4, resulting in a Glu123Lys substitution in the protein sequence.ConclusionsThe uncommon clinical pattern (high seizure frequency, drug-resistance) highlights the variability of the ADLTE phenotype and extends our knowledge of the clinical spectrum associated with LGI1 mutations.

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