• Gen Hosp Psychiatry · Jan 2011

    Review Case Reports

    A case of delirium, motor disturbances, and autonomic dysfunction due to baclofen and tizanidine withdrawal: a review of the literature.

    • David E Karol, Andrew J Muzyk, and Xavier A Preud'homme.
    • Duke University Medical Center, Durham, NC 27705, USA. david.karol@duke.edu
    • Gen Hosp Psychiatry. 2011 Jan 1; 33 (1): 84.e1-2.

    AbstractWe report a case of delirium accompanied by extrapyramidal symptoms and autonomic dysfunction in a 59-year-old man following abrupt cessation of baclofen and tizanidine. An extensive search for the etiology was undertaken, but it was only after a careful history was taken that suspicion for baclofen and tizanidine withdrawal was raised. The delirium and motor disturbances resolved within 24 h of reintroduction of baclofen. Withdrawal from muscle relaxants requires a high index of suspicion but should be considered in patients who manifest signs and symptoms of withdrawal from the medications, particularly visual hallucinations, rigidity and autonomic dysfunction.Copyright © 2011 Elsevier Inc. All rights reserved.

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