• David Hui, Rony Dev, Lindsay Pimental, Minjeong Park, Maria A Cerana, Diane Liu, and Eduardo Bruera.
• Department of Palliative Care and Rehabilitation Medicine, MD Anderson Cancer Center, Houston, USA. Electronic address: dhui@mdanderson.org.
• J Pain Symptom Manage. 2017 Mar 1; 53 (3): 571-577.

ContextThe ability to predict survival accurately has implications in clinical decision making.ObjectivesWe determined the association of phase angle obtained from multi-frequency bioelectric impedance analysis with overall survival in patients with advanced cancer.MethodsWe included consecutive patients with advanced cancer who had an outpatient palliative care consultation. Multi-frequency bioelectric impedance analysis assessed phase angle at three different frequencies (5/50/250 kHz) on each hemibody (right/left). Survival analysis was conducted using the Kaplan-Meier method, log-rank test, and multivariate Cox regression analysis.ResultsAmong 366 patients, the median overall survival was 250 days (95% confidence interval 191-303 days). The mean phase angle for 5, 50, and 250 kHz were 2.2°, 4.4°, and 4.2° on the right and 2.0°, 4.2° and 4.1° on the left, respectively. For all six phase angles, a lower value was significantly associated with a poorer overall survival (P < 0.001). After adjusting for cancer type, performance status, weight loss, and inflammatory markers, phase angle remained independently associated with overall survival (hazard ratio 0.85 per degree increase, 95% confidence interval 0.72-0.99; P = 0.048).ConclusionPhase angle represents a novel objective prognostic factor in outpatient palliative cancer care setting, regardless of frequency and body sides.Copyright © 2016 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

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