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- Kamrouz Ghadimi, Keith E Dombrowski, Jerrold H Levy, and Ian J Welsby.
- a Divisions of Cardiothoracic Anesthesiology & Critical Care Medicine , Duke University Medical Center , Durham , NC , USA.
- Expert Rev Hematol. 2016 Jan 1; 9 (2): 115-22.
AbstractAndexanet alfa is a specific reversal agent for Factor Xa inhibitors. The molecule is a recombinant protein analog of factor Xa that binds to Factor Xa inhibitors and antithrombin:LMWH complex but does not trigger prothrombotic activity. In ex vivo, animal, and volunteer human studies, andexanet alfa (AnXa) was able to dose-dependently reverse Factor Xa inhibition and restore thrombin generation for the duration of drug administration. Further trials are underway to examine its safety and efficacy in the population of patients experiencing FXa inhibitor-related bleeding.
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