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- Jean-Pierre G Changeux.
- Collège de France and Institut Pasteur, Paris, France. changeux@noos.fr
- Curr Opin Anaesthesiol. 2012 Aug 1;25(4):397-404.
Purpose Of ReviewCan a general anesthetic binding to its membrane receptors alter global brain activity to cause loss of consciousness?Recent FindingsThe identification of the neurobiological mechanisms of conscious processing in awake patients that are altered by general anesthetics and the atomic structure of the general anesthetic's binding site.SummaryAn important feature of general anesthesia is a preferential inhibition of global feedback connectivity when general anesthetics bind to allosteric sites of gamma-aminobutyric acid receptors present in the cerebral cortex.
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