• Christopher J Coyne, Vivian Le, Jesse J Brennan, Edward M Castillo, Rebecca A Shatsky, Karen Ferran, Stephanie Brodine, and Gary M Vilke.
• Department of Emergency Medicine, University of California San Diego School of Medicine, San Diego, CA. Electronic address: cjcoyne@ucsd.edu.
• Ann Emerg Med. 2017 Jun 1; 69 (6): 755-764.

Study ObjectiveAlthough validated risk-stratification tools have been used to send low-risk febrile neutropenic patients home from clinic and inpatient settings, there is a dearth of research evaluating these scores in the emergency department (ED). We compare the predictive accuracy of the Multinational Association for Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE) scores for patients with chemotherapy-induced febrile neutropenia and presenting to the ED.MethodsWe conducted a retrospective cohort study to evaluate all patients with febrile neutropenia (temperature ≥38°C [100.4°F], absolute neutrophil count <1,000 cells/μL) who presented to 2 academic EDs from June 2012 through January 2015. MASCC and CISNE scores were calculated for all subjects, and each visit was evaluated for several outcome variables, including inpatient length of stay, upgrade in level of care, clinical deterioration, positive blood culture results, and death. Descriptive statistics are reported and continuous variables were analyzed with Wilcoxon rank sum.ResultsDuring our study period, 230 patients presented with chemotherapy-induced febrile neutropenia. The CISNE score identified 53 (23%) of these patients as low risk and was highly specific in the identification of a low-risk cohort for all outcome variables (98.3% specific, 95% confidence interval [CI] 89.7% to 99.9%; positive predictive value 98.1%, 95% CI 88.6% to 99.9%). Median length of stay was shorter for low-risk versus high-risk CISNE patients (3-day difference; P<.001). The MASCC score was much less specific (54.2%; 95% CI 40.8% to 67.1%) in the identification of a low-risk cohort.ConclusionOur results suggest that the CISNE score may be the most appropriate febrile neutropenia risk-stratification tool for use in the ED.Copyright © 2016 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.

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