• The lancet oncology · Jun 2015

    Review

    Sequencing of agents in castration-resistant prostate cancer.

    • David Lorente, Joaquin Mateo, Raquel Perez-Lopez, Johann S de Bono, and Gerhardt Attard.
    • Prostate Cancer Targeted Therapy Group, The Institute of Cancer Research and the Royal Marsden NHS Foundation Trust, London, UK.
    • Lancet Oncol. 2015 Jun 1; 16 (6): e279-92.

    AbstractUntil 2010, docetaxel was the only agent with proven survival benefit for castration-resistant prostate cancer. The development of cabazitaxel, abiraterone acetate, enzalutamide, radium-223, and sipuleucel-T has increased the number of treatment options. Because these agents were developed concurrently within a short period of time, prospective data on their sequential use efficacy are scarce. The challenge now is to reach a consensus on the best way to sequence effective treatments, ideally by the use of an approach specific to patient subgroups. However, the absence of robust surrogates of survival and the lack of predictive biomarkers makes data for the sequential use of these agents difficult to obtain and interpret. Copyright © 2015 Elsevier Ltd. All rights reserved.

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