• The lancet oncology · Jun 2015

    Review

    Next-generation (epi)genetic drivers of childhood brain tumours and the outlook for targeted therapies.

    • Paul A Northcott, Stefan M Pfister, and David T W Jones.
    • Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: paul.northcott@stjude.org.
    • Lancet Oncol.. 2015 Jun 1;16(6):e293-302.

    AbstractArguably, nowhere has there been a greater advance in our understanding of biological mechanisms and potential translational targets during the next-generation sequencing era than in paediatric brain tumours. The so-called omics revolution, enabled by high-throughput sequencing, has empowered large consortia and independent groups alike to make major genetic discoveries, from dominant-negative histone mutations and hijacking of distal enhancer elements, to new oncogenic gene fusions and aberrantly active gene expression. Epigenetic deregulation has also been revealed as a common theme across several tumour subtypes. This Review focuses on key findings that have been transforming the landscape of paediatric neuro-oncology research and how these results are opening new avenues towards potential therapeutic translation.Copyright © 2015 Elsevier Ltd. All rights reserved.

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