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Multicenter Study
Age-related differences in the frequency of ketoacidosis at diagnosis of type 1 diabetes in children and adolescents.
- Anne Hekkala, Antti Reunanen, Matti Koski, Mikael Knip, Riitta Veijola, and Finnish Pediatric Diabetes Register.
- Department of Pediatrics, University of Oulu, Oulu University Hospital, Oulu, Finland. anne.hekkala@oulu.fi
- Diabetes Care. 2010 Jul 1; 33 (7): 1500-2.
ObjectiveWe studied the prevalence of diabetic ketoacidosis (DKA) at diagnosis of type 1 diabetes in children in Finland.Research Design And MethodsFrom 2002 to 2005, data on virtually all children <15 years of age diagnosed with type 1 diabetes (n = 1,656) in Finland were collected.ResultsDKA was present in 19.4% of the case subjects, and 4.3% had severe DKA. In children aged 0-4, 5-9, and 10-14 years, DKA was present in 16.5, 14.8, and 26.4%, respectively (P < 0.001). Severe DKA occurred in 3.7, 3.1, and 5.9%, respectively (P = 0.048). DKA was present in 30.1% and severe DKA in 7.8% of children aged <2 years.ConclusionThe overall frequency of DKA in children is low in Finland at diagnosis of type 1 diabetes. However, both children <2 years of age and adolescents aged 10-14 years are at increased risk of DKA.
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