• M Coppens, S Anssens, A Parashchanka, K Roelens, E Deschepper, S De Hert, and P F Wouters.
• Department of Anaesthesiology and Peri-operative Medicine, Ghent University Hospital, Ghent, Belgium.
• Anaesthesia. 2017 May 1; 72 (5): 598-602.

AbstractThe primary goal of this study was to determine the median effective dose (ED50 ) of spinal chloroprocaine for labour analgesia. Thirty-eight parturients requesting neuraxial analgesia were enrolled. Doses of 1% chloroprocaine were determined by the technique of up-down sequential allocation, with an initial dose of 20 mg and steps of 2 mg. The chloroprocaine spinal dose was given as the spinal component of a combined spinal-epidural, which was then supplemented with an epidural dose of 7.5 μg sufentanil in 7 ml saline. Effective analgesia was defined as a score ≤ 10 mm within 15 min on a 100-mm visual analogue pain scale. Using the isotonic regression estimator method, the ED50 of chloroprocaine for the spinal component of a combined spinal-epidural for labour was calculated to be median (95%CI) 12.0 (9.3-17.0) mg.© 2017 The Association of Anaesthetists of Great Britain and Ireland.

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