• Yasser Sami Amer, Mahmoud Munir Elzalabany, Tarek Ismael Omar, Afaf Gaber Ibrahim, and Nabil Lotfy Dowidar.
• Alexandria Center for EBCPGs, Healthcare Quality Directorate, University New Hospital, Faculty of Medicine Alexandria University, Alexandria, Egypt.
• J Eval Clin Pract. 2015 Dec 1; 21 (6): 1095-106.

Rationale, Aims And ObjectivesThe ADAPTE methodology for adaptation of guidelines has been used by many organizations to develop high-quality clinical practice guidelines. Although it is a valid alternative for de novo development of guidelines, it might demand more time and resources in some institutions. The present study demonstrates the proposed 'adapted ADAPTE' methodology to support more clarity, simplicity and practicality. It also aims at avoiding duplication within the process and reducing the resources and time allocated to the CPG adaptation projects.MethodsClinical guidelines' adaptation in the Center for Evidence-Based Clinical Practice Guidelines at the Alexandria Faculty of Medicine and University Hospitals involves two stages: (1) cross-sectional or retrospective study to reveal the current practice and prescribing patterns concerning the selected health topic; (2) the 'adapted ADAPTE' methodology for CPGs adaptation that was based on the original ADAPTE Process.ResultsThe 'adapted ADAPTE' included three modified tools, three new tools based on the original ADAPTE framework and alternatives for four ADAPTE steps to enhance utilization. The finalized adapted CPGs included nine high priority topics for paediatrics and two topics for emergency medicine.ConclusionsThe ADAPTE methodology for guideline adaptation can be customized or 'adapted' to the local health care setting and resources. This proposal facilitates supports and improves the utilization and update of the ADAPTE process by CPG programmes or activities in health care organizations. This is of particular importance in health care systems in developing countries with limited resources in the Eastern Mediterranean region like Egypt.© 2015 John Wiley & Sons, Ltd.

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