• The lancet oncology · Jul 2015

    Review

    Diagnosis and treatment of primary CNS lymphoma in immunocompetent patients: guidelines from the European Association for Neuro-Oncology.

    • Khê Hoang-Xuan, Eric Bessell, Jacoline Bromberg, Andreas F Hottinger, Matthias Preusser, Roberta Rudà, Uwe Schlegel, Tali Siegal, Carole Soussain, Ufuk Abacioglu, Nathalie Cassoux, Martina Deckert, Clemens M F Dirven, Andrés J M Ferreri, Francesc Graus, Roger Henriksson, Ulrich Herrlinger, Martin Taphoorn, Riccardo Soffietti, Michael Weller, and European Association for Neuro-Oncology Task Force on Primary CNS Lymphoma.
    • Assistance Publique des Hôpitaux de Paris, Department of Neurology Mazarin, Hôpital Pitié-Salpêtrière, Université Pierre et Marie Curie, Institut Hospitalo-Universitaire, Institut du Cerveau et de la Moelle, Inserm Unit 1125, UMR Unit 7225, Lymphome Oculo Cerebral Network, Paris, France. Electronic address: khe.hoang-xuan@psl.aphp.fr.
    • Lancet Oncol. 2015 Jul 1;16(7):e322-32.

    AbstractThe management of primary CNS lymphoma is one of the most controversial topics in neuro-oncology because of the complexity of the disease and the very few controlled studies available. In 2013, the European Association of Neuro-Oncology created a multidisciplinary task force to establish evidence-based guidelines for immunocompetent adults with primary CNS lymphoma. In this Review, we present these guidelines, which provide consensus considerations and recommendations for diagnosis, assessment, staging, and treatment of primary CNS lymphoma. Specifically, we address aspects of care related to surgery, systemic and intrathecal chemotherapy, intensive chemotherapy with autologous stem-cell transplantation, radiotherapy, intraocular manifestations, and management of elderly patients. The guidelines should aid clinicians in their daily practice and decision making, and serve as a basis for future investigations in neuro-oncology.Copyright © 2015 Elsevier Ltd. All rights reserved.

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