• Br J Surg · Jan 2017

    Review

    Importance of biofilm formation in surgical infection.

    • S L Percival.
    • 5D Health Protection Group Ltd, Liverpool Bio-Innovation Hub, William Duncan Building, West Derby Street, Liverpool L7 8TX, UK.
    • Br J Surg. 2017 Jan 1; 104 (2): e85-e94.

    BackgroundBiofilms are ubiquitous, and have been observed in both acute and chronic wounds. Their role in wound healing and infection, however, remains controversial. The aim of this review was to provide an overview of the role and relevance of biofilms to surgical wounds.MethodsA search of PubMed, Science Direct and Web of Science databases was performed to identify studies related to biofilms. Specifically, studies were sought in acute and chronic wounds, and the management and treatment of non-healing and infected skin and wounds.ResultsBiofilms may develop in all open wounds. In chronic wounds, biofilms may play a role in prolonging and preventing healing, causing chronic inflammation and increasing the risk of infection. Controversies exist regarding the methods presently employed for biofilm detection and management and few data exist to underpin these decisions.ConclusionBiofilms in acute surgical and chronic wounds appear to cause a delay in healing and potentially increase the risk of infection. Biofilms can be prevented and once developed can be controlled using wound desloughing and debridement.© 2017 BJS Society Ltd Published by John Wiley & Sons Ltd.

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