• JAMA · Jan 2017

    Comment

    Associations of Antifungal Treatments With Prevention of Fungal Infection in Critically Ill Patients Without Neutropenia.

    • Andrea Cortegiani, Vincenzo Russotto, and Antonino Giarratano.
    • Department of Biopathology and Medical Biotechnologies, Section of Anesthesia Analgesia Intensive Care and Emergency, University of Palermo, Palermo, Italy.
    • JAMA. 2017 Jan 17; 317 (3): 311-312.

    Clinical QuestionAre antifungal agents associated with lower rates of mortality and invasive fungal infections when administered before definitive diagnosis of an invasive fungal infection in critically ill patients without neutropenia?Bottom LineAntifungal treatment administered prior to diagnosis of an invasive fungal infection is not associated with either higher or lower rates of all-cause mortality. Antifungal treatment in this setting is associated with lower rates of invasive fungal infections compared with placebo or no intervention in critically ill patients without neutropenia, but the quality of the evidence is low.

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