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Neurological research · Oct 2014
Association study of TREM2 polymorphism rs75932628 with late-onset Alzheimer's disease in Chinese Han population.
- Jianfang Ma, Yi Zhou, Jun Xu, Xiaohong Liu, Ying Wang, Yulei Deng, Gang Wang, Wei Xu, Rujin Ren, Xiaoying Liu, Yu Zhang, Cheng Wang, Huidong Tang, and Shengdi Chen.
- Neurol. Res. 2014 Oct 1; 36 (10): 894-6.
ObjectiveWe conducted a case-control study to investigate whether TREM2 polymorphism (rs75932628-T) was associated with late onset Alzheimer's disease in Chinese Southern Han population.MethodsPCR-restriction fragment length polymorphism assay was performed to genotype rs75932628 in 279 cases with late onset Alzheimer's diseases patients and 346 control subjects in Shanghai and Nanjing.ResultsThere was no rs75932628-T variant detected in our sample. However, APOEϵ4 was shown closely associated with the risk of Alzheimer's disease (Chi-square = 60·288, P = 0·000).ConclusionOur study suggested that TREM2 (rs75932628-T) was rare in Chinese Han population. Further association studies with large samples are needed to further study the association of TREM2 with late-onset Alzheimer's disease.
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