• Xin Zhao, Yun-Xia Chen, and Chun-Sheng Li.
• Emergency Department, Beijing Chao-Yang Hospital, Capital Medical University, Chaoyang District, Beijing 100020, China.
• Biomark Med. 2015 Jan 1; 9 (7): 661-8.

AimTo investigate the prognostic performance of complement components in septic patients, complement 3, membrane attack complex (MAC) and mannose-binding lectin were measured and compared among adult patients with sepsis, severe sepsis and septic shock, as well as between in-hospital nonsurvivors and survivors.MethodsThe prognostic value of complement components was compared with mortality in emergency department sepsis (MEDS) score.ResultsMedian complement 3, MAC and mannose-binding lectin increased directly with the sepsis, severe sepsis and septic shock groups, and were significantly higher in nonsurvivors than in survivors.ConclusionMEDS and MAC independently predicted in-hospital mortality. The prognostic performance of MAC was superior to MEDS as analyzed by receiver operating characteristic curve and area under the curve.

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