• Clinics in chest medicine · Dec 1996

    Review

    Immunologic effects of HIV in the lung.

    • C Agostini and G Semenzato.
    • Department of Clinical and Experimental Immunology, Padua University School of Medicine, Padova, Italy.
    • Clin. Chest Med. 1996 Dec 1; 17 (4): 633-45.

    AbstractThis article covers a selected group of topics dealing with the contribution of lung immunocompetent cells in the host defense mechanisms against HIV. These include recent findings suggesting that bidirectional signals between alveolar macrophages and pulmonary cytotoxic T lymphocytes define regulatory networks, which contribute to the accumulation of HIV-specific effector cells in the lung microenvironment. The authors also emphasize the cell pattern of HIV infection in the lung, highlighting the role of the retrovirus in weakening pulmonary host defenses and its spreading into the lower respiratory tract.

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