Randomized Controlled Trial
Biased agonism of the mu opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: a randomized, double-blind placebo-controlled crossover study in healthy volunteers.
Pain. 2014 Sep 1; 155 (9): 1829-1835.
Randomized Controlled Trial
First clinical experience with TRV130: pharmacokinetics and pharmacodynamics in healthy volunteers.
J Clin Pharmacol. 2014 Mar 1;54(3):351-7.
Article
Polymorphism of μ-Opioid Receptor Gene (OPRM1:c.118A>G) Might Not Protect against or Enhance Morphine-Induced Nausea or Vomiting.
Pain Res Treat. 2013 Jan 1; 2013: 259306.