• Zachary David Levy, Megan Slowey, and Michael Schulder.
• Department of Emergency Medicine, Hofstra Northwell School of Medicine, 500 Hofstra Boulevard, Hempstead, NY 11549, United States; Department of Neurosurgery, Hofstra Northwell School of Medicine, 500 Hofstra Boulevard, Hempstead, NY 11549, United States. Electronic address: zlevy@northwell.edu.
• Am J Emerg Med. 2017 Jul 1; 35 (7): 1036.e1-1036.e2.

AbstractAcute generalized exanthematous pustulosis (AGEP) is a rare cutaneous eruption characterized by the appearance of diffuse, sterile pustules on an erythematous and edematous base. Most cases are attributed to drug reactions, with antibiotics being the most common offending agents. Only a handful of case reports have described AGEP in the setting of antiepileptic use. Here, we report a case of AGEP secondary to dual antiepileptic therapy with levetiracetam and valproic acid in a 73-year-old female. The patient presented to the emergency department with the characteristic AGEP rash, fever, and leukocytosis. Upon discontinuation of the two medications and conservative management, the patient's symptoms quickly abated, and she was discharged from the hospital several days later.Copyright © 2017 Elsevier Inc. All rights reserved.

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