• Expert Rev Clin Immunol · Jan 2015

    Review

    The evolution of allergen and non-specific immunotherapy: past achievements, current applications and future outlook.

    • Giovanni B Pajno, Kari C Nadeau, Giovanni Passalacqua, Lucia Caminiti, Ben Hobson, David C Jay, Stefania Arasi, Fernanda Chiera, and Giuseppina Salzano.
    • Department of Pediatrics- Allergy Unit, University of Messina, Via Consolare Valeria-Gazzi, 98124 Messina, Italy.
    • Expert Rev Clin Immunol. 2015 Jan 1; 11 (1): 141-54.

    AbstractRecent epidemiological studies estimated that more than 30% of European suffer from allergic rhinitis or conjunctivitis, while up to 20% suffer from asthma and 15% from allergic skin conditions, while for many other regions the prevalence is increasing. Allergen immunotherapy represents the only available treatment that can modify the allergic disease process, and thus is worth considering as a treatment in affected individuals. A beneficial effect of allergen immunotherapy has been shown in both adults and children affected by allergic rhinitis, allergic conjunctivitis, allergic asthma and hymenoptera venom allergy. The present study represents an overview on allergen immunotherapy, focusing on the principal aspects of the use of immunotherapy in the past, its recent clinical applications and future outlook.

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