• The lancet oncology · Oct 2013

    Review

    Is cancer gene therapy an empty suit?

    • Malcolm K Brenner, Stephen Gottschalk, Ann M Leen, and Juan F Vera.
    • Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital, Houston, TX, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA; Department of Medicine, Baylor College of Medicine, Houston, TX, USA. Electronic address: mbrenner@bcm.edu.
    • Lancet Oncol. 2013 Oct 1; 14 (11): e447e456e447-e456.

    AbstractGene therapy as a treatment for cancer is regarded as high in promise, but low in delivery, a deficiency that has become more obvious with ever-increasing reports of the successful correction of monogenic disorders by this approach. We review the commercial and scientific obstacles that have led to these delays and describe how they are progressively being overcome. Recent and striking successes and correspondingly increased commercial involvement suggest that gene transfer could finally become a powerful method for development of safe and effective cancer therapeutic drugs.Copyright © 2013 Elsevier Ltd. All rights reserved.

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