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Kidney international · Apr 2016
EditorialProton pump inhibitors and chronic kidney disease: is it time to sound the alarm?
- Christina M Wyatt.
- Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address: christina.wyatt@mssm.edu.
- Kidney Int. 2016 Apr 1; 89 (4): 732-3.
AbstractProton pump inhibitors are widely used worldwide for the management of gastroesophageal reflux, but have been associated with the development of interstitial nephritis and acute kidney injury. A large observational study using data from the Atherosclerosis Risk in Communities cohort and the Geisinger Health System demonstrates an association between the use of proton pump inhibitors and chronic kidney disease. Although the study does not prove causality, the robustness of the findings in two cohorts suggests a need for further study and reevaluation of the safety of these agents for widespread, non-prescription use.Copyright © 2016 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
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