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Case Reports
[Dilated cardiomyopathy and lipid-lowering drug muscle toxicity revealing late-onset Becker's disease].
- M A Vandenhende, F Bonnet, L Sailler, S Bouillot, P Morlat, and J Beylot.
- Service de médecine interne et maladies infectieuses, hôpital Saint-André, 1, rue Jean-Burguet, 33075 Bordeaux cedex, France.
- Rev Med Interne. 2005 Dec 1; 26 (12): 977-9.
IntroductionThe Becker's muscular dystrophy is a genetic myopathy due to mutations of the dystrophin gene, located in the Xp21 region, with a clinical expression usually occurring in young adults.ExegesisWe report an atypical case of late onset Becker's muscular dystrophy diagnosed at the age of 57. The patient suffered from mild skeletal muscle involvement revealed by the use of statins and fibrates, associated with severe dilating cardiomyopathy. The DNA analysis showed a deletion of the exons 11-13 in the Xp21 gene.ConclusionThe diagnostic of Becker's muscular dystrophy must be considered in all patients with persistently elevated CPK and/or primitive dilated cardiomyopathy, whatever the age of the patient.
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