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Biochem. Biophys. Res. Commun. · Jul 1992
Volatile anesthetics selectively alter [3H]ryanodine binding to skeletal and cardiac ryanodine receptors.
- T J Connelly, R E Hayek, B F Rusy, and R Coronado.
- Department of Anesthesiology, University of Wisconsin-Madison 53792.
- Biochem. Biophys. Res. Commun. 1992 Jul 15; 186 (1): 595-600.
AbstractThe effect of clinical concentrations of volatile anesthetics on ryanodine receptors of cardiac and skeletal muscle sarcoplasmic reticulum was evaluated using [3H]ryanodine binding. At 2 volume percent, halothane and enflurane stimulated binding to cardiac SR by 238% and 204%, respectively, while isoflurane had no effect. In contrast, halothane and enflurane had no effect on [3H]ryanodine binding to skeletal ryanodine receptors, while isoflurane produced a significant stimulation. These results suggest that volatile anesthetics interact in a site-specific manner with ryanodine receptors of cardiac or skeletal muscle to effect Ca2+ release-channel gating.
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