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- Suzanne Nielsen, Briony Larance, and Nicholas Lintzeris.
- National Drug and Alcohol Centre, University of New South Wales, Sydney, Australia.
- JAMA. 2017 Mar 7; 317 (9): 967-968.
Clinical QuestionAre different opioid agonist treatments (eg, methadone vs buprenorphine) associated with differences in efficacy for treating prescription opioid dependence, and is long-term maintenance of opioid agonist treatment associated with differences in efficacy compared with opioid taper or psychological treatments alone?Bottom LineFor patients who are dependent on prescription opioids, long-term maintenance of opioid agonists is associated with less prescription opioid use and better adherence to medication and psychological therapies for opioid dependence compared with opioid taper or psychological treatments alone. Methadone maintenance was not associated with differences in therapeutic efficacy compared with buprenorphine maintenance treatment. Evidence quality was low to moderate.
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