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- Joe Hong, Jooyeon Lee, Holly Totouom-Tangho, Norma Ramos Dunn, and Ronnie Gorman Swift.
- Department of Psychiatry, Metropolitan Hospital Center, New York Medical College, New York, NY.
- J Addict Med. 2017 May 1; 11 (3): 237-238.
ObjectivesThis case report aims to help healthcare providers and methadone clinic patients to recognize one of the less recognized adverse effects of methadone, hyperhidrosis, and to suggest oxybutynin as a possible solution.MethodsA 35-year-old man on methadone maintenance therapy presented with excessive sweating, which began promptly after methadone was introduced. Urine toxicology was conducted every 2 weeks to rule out other illicit substances that may have contributed to the sweating.ResultsOxybutynin (5 mg PO QID) resulted in cessation of the methadone-induced hyperhidrosis within 2 days of starting the medication.ConclusionsMethadone-induced excessive sweating is an adverse effect of the medication that reportedly affects up to 45% of those prescribed methadone, and oxybutynin is a potent treatment for methadone-induced excessive sweating.
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