• J Drugs Dermatol · Apr 2006

    Case Reports

    Nicolau syndrome: a report of 2 cases.

    • Sharad Mutalik and Vasudha Belgaumkar.
    • Department of Dermatology, Maharashtra Medical Foundation, Pune, India. mruganka@vsnl.com
    • J Drugs Dermatol. 2006 Apr 1; 5 (4): 377-8.

    AbstractNicolau syndrome or embolia cutis medicamentosa is a very rare, but well recognized complication of intramuscular injections which clinically presents with extensive necrosis of the injected skin area. Intra-arterial or para-arterial injection after unintentional perforation of certain vessels could be the possible mechanisms. We describe 2 cases of Nicolau syndrome resulting from intramuscular injection of Diclofenac. Since irreversible tissue damage may occur within a short duration and, as the there is no definitive treatment for this condition, precautionary measures are emphasized.

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