• G Sommer, B Noorbehesht, N Pelc, R Jamison, A J Pinevich, L Newton, and B Myers.
• Department of Radiology, Stanford University School of Medicine, California 94305.
• Invest Radiol. 1992 Jun 1; 27 (6): 465-70.

Rationale And ObjectivesThis study assesses the ability of a cardiac-gated phase-contrast magnetic resonance imaging (MRI) technique to measure renal blood flow (RBF) noninvasively in humans.MethodsIn nine normal volunteers, total RBF in the renal arteries and in the left renal vein was estimated by MRI and correlated with RBF determined by the clearance of para-aminohippuric acid (CPAH) and the hematocrit level.ResultsCorrelation of RBF estimated from left renal vein flow, with RBF by CPAH-hematocrit, yielded r = .86 (P less than .003). Repeated measurement of RBF by MRI demonstrated a high degree of reproducibility, with coefficients of variation ranging from 4.8% to 8.9%. However, the MRI measurements of arterial flow did not significantly correlate with the standard measurements.ConclusionsReproducible noninvasive measurement of normal RBF is possible with the phase-contrast MRI technique used to measure renal venous blood flow.

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