• Taku Yamamichi, Takaharu Oue, Takeo Yonekura, Mitsugu Owari, Kengo Nakahata, Satoshi Umeda, Keigo Nara, Takehisa Ueno, Shuichiro Uehara, and Noriaki Usui.
• Department of Surgery, Division of Pediatric Surgery, Osaka University Graduate School of Medicine, Japan.
• J. Pediatr. Surg. 2015 May 1; 50 (5): 833-6.

Background/PurposeAlthough the usefulness of intraoperative indocyanine green (ICG) fluorescent imaging for the resection of hepatocellular carcinoma has been reported, its usefulness for the resection of hepatoblastoma remains unclear. This study clarifies the feasibility of intraoperative ICG fluorescent imaging for the resection of hepatoblastoma.MethodsIn three hepatoblastoma patients, a primary tumor, recurrent tumor, and lung metastatic lesions were intraoperatively examined using a near-infrared fluorescence imaging system after the preoperative administration of ICG.ResultsICG fluorescent imaging was useful for the surgical navigation in hepatoblastoma patients. In the first case, the primary hepatoblastoma exhibited intense fluorescence during right hepatectomy, but no fluorescence was detected in the residual liver. In the second case, a recurrent tumor exhibited fluorescence between the residual liver and diaphragm. A complete resection of the residual liver, with a partial resection of the diaphragm, followed by liver transplantation was performed. In the third case with multiple lung metastases, each metastatic lesion showed positive fluorescence, and all were completely resected. These fluorescence-positive lesions were pathologically proven to be viable hepatoblastoma cells.ConclusionIntraoperative ICG fluorescence imaging for patients with hepatoblastoma was feasible and useful for identifying small viable lesions and confirming that no remnant tumor remained after resection.Copyright © 2015 Elsevier Inc. All rights reserved.

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