• The lancet oncology · Mar 2014

    Review

    Microbiota and radiation-induced bowel toxicity: lessons from inflammatory bowel disease for the radiation oncologist.

    • Miguel R Ferreira, Ann Muls, David P Dearnaley, and H Jervoise N Andreyev.
    • Institute of Cancer Research, London, UK; Royal Marsden NHS Foundation Trust, London, UK; Instituto Gulbenkian Ciencia, Oeiras, Portugal. Electronic address: jferreira@icr.ac.uk.
    • Lancet Oncol. 2014 Mar 1; 15 (3): e139-47.

    AbstractNew gastrointestinal symptoms are frequent after pelvic radiotherapy and can greatly affect the quality of life of cancer survivors. The effect of radiation on the intestinal microbiota, and the clinical implications of a modified microbial balance after radiotherapy are now beginning to emerge. In this Personal View, we show the importance of the microbiota for intestinal homoeostasis, and discuss the similarity between inflammatory bowel disease, which has been extensively researched, and radiation-induced gastrointestinal toxicity. By use of microbiota profiles for risk assessment and manipulation of the intestinal flora for prevention and treatment of radiation, enteropathy could become a reality and would be of substantial relevance to the increasing numbers of long-term cancer survivors. Copyright © 2014 Elsevier Ltd. All rights reserved.

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